5/26/2023 0 Comments Neural crest cellsIn our previous work, extracellular vesicles (EVs) secreted by stem cells from human exfoliated deciduous teeth (SHED) offered new insights as potential strategies for functional recovery of TBI. However, no effective therapeutics have been developed yet. Traumatic brain injury (TBI) contributes to the key causative elements of neurological deficits. This review explored functional ECM components involved in odontogenic differentiation and dental tissue regeneration. Therefore, elucidating the effect of the functional ECM on odontogenic differentiation and its mechanism has great scientific significance and potential clinical application. At present, the function and regulatory mechanism of the functional ECM in this process remain poorly understood. The functional ECM consists of extracellular components that control the initiation and growth of crystal deposition and regulate the differentiation and regeneration of endogenous or exogenous stem cells in the defect site. Cell type, extracellular matrix (ECM) environment, cytokines and other factors which affect odontogenic differentiation and dental tissue regeneration have aroused significant interest. With the development of tissue engineering technology, dental tissue regeneration has emerged as a promising technique. Dental defects and loss are common oral diseases that seriously affect the chewing efficiency of patients and thereby affect their health.
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